Genetic meta-analysis of diagnosed Alzheimer’s disease

Published

December 8, 2020

This study identified new risk loci and implicated Aβ, tau, immunity and lipid processing.

Resuts

Genome-wide-significant associations:

  • R47H TREM2 coding variant: triggering receptor expressed in myeloid cells 2. With its antiinflammatory role, the P47H mutation may affect the brain’s ability to prevent the buildup of plaque.

  • ECHDC3: may be part of fatty acid biosynthesis and insulin sensitivity

  • ACE: aangiotensin-converting enzyme.

Suggestive association:

  • ADAM10: stabilization and regulation of the molecular optimization of the glutamatergic synapse.

  • ADAMGS1:

  • IQCK:

  • ACE